Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair
Publication in refereed journal

替代計量分析
.

其它資訊
摘要Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that Yap1, an effector of Hippo pathway inhibits skeletal development, postnatal growth, and bone repair. We show that Yap1 regulates chondrocyte differentiation at multiple steps in which it promotes early chondrocyte proliferation but inhibits subsequent chondrocyte maturation both in vitro and in vivo. Mechanistically, we find that Yap1 requires Teads binding for direct regulation of Sox6 expression to promote chondrocyte proliferation. In contrast, Yap1 inhibits chondrocyte maturation by suppression of Col10a1 expression through interaction with Runx2. In addition, Yap1 also governs the initiation of fracture repair by inhibition of cartilaginous callus tissue formation. Taken together, our work provides insights into the mechanism by which Yap1 regulates endochondral ossification, which may help the development of therapeutic treatment for bone regeneration.
著者Deng YJ, Wu AL, Li PS, Li G, Qin L, Song H, Mak KK
期刊名稱Cell Reports
出版年份2016
月份3
日期8
卷號14
期次9
出版社CELL PRESS
頁次2224 - 2237
國際標準期刊號2211-1247
語言美式英語

上次更新時間 2021-02-03 於 01:40