Evaluating the relationships between body composition, muscle strength and bone quality parameters in girls with adolescent idiopathic scoliosis (AIS)
Refereed conference paper presented and published in conference proceedings


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摘要Introduction:
Muscle exerts dynamic mechanical loads to promote bone formation, and decrease in muscle mass was shown to be linked to osteoporosis. The deranged bone quality associated with AIS could be contributed by low muscle mass. This study aimed to investigate the correlations between body composition, grip strength and bone quality parameters in AIS versus controls.

Methods:
183 AIS girls aged 12 to 14 with different curve severity (Cobb angle 10-72°) and 169 age-matched control girls were recruited. Skeletal muscle mass (SMM), fat-free mass (FFM), and body fat mass (BFM) were measured with bioelectrical impedance analysis. Grip strength of both hands were measured by dynamometer. Bilateral femoral neck bone mineral densities (FNBMDs) and non-dominant distal radius were measured by DXA and HR-pQCT respectively.

Results:
AIS girls have lower SMM, FFM, BFM, grip strength, bilateral FNBMDs, average volumetric BMD (vBMD), and cortical bone parameters (vBMD, thickness, area) compared with controls. In correlations with bone quality parameters, AIS group showed generally weaker correlations with SMM and stronger correlations with BFM after age and arm span adjustment. Multiple linear regression showed that correlations between BFM and FNBMDs were significantly different between AIS and controls, while correlations between SMM, non-dominant FNBMD and grip strength were marginal (p<0.1).

Discussion:
This study provided some evidence that bone in AIS girls could respond differently to biochemical and mechanical stimuli exerted by muscle and adipose tissues. Study into fat-bone and muscle-bone interactions could provide more in-depth understanding on the etiology of low bone mass in AIS.
著者E. M. S. Tam, F. W. P. Yu, V. W. Y. Hung, L. Qin, J. C. Y. Cheng, T. P. Lam
會議名稱11th International Congress of Chinese Orthopaedic Association (COA)
會議開始日17.11.2016
會議完結日20.11.2016
會議地點Beijing, China
會議國家/地區中國
出版年份2016
語言英式英語

上次更新時間 2018-22-01 於 09:17