Combined effects of metronomic zoledronate with Coriolus versicolor in a metastatic breast tumor mouse model
Refereed conference paper presented and published in conference proceedings


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AbstractIncidence of breast cancer is high in women worldwide and mortality usually results from tumor metastasis. Adjuvant
chemotherapeutic, such as zoledronate (ZOL), has been used in metastatic breast cancer mainly for skeletal protection. Our previous studies demonstrated that Coriolus versicolor (CV) aqueous extract exhibited anti-tumor and
anti-metastatic effects in breast tumor mouse model, and together with repeated low dose (metronomic) of ZOL
exerted anti-osteolysis effects in intratibial breast cancer-induced osteolysis model. In this study, the combined action of metronomic ZOL and CV was further investigated on breast tumor metastasis and immunomodulation in metastatic breast tumor mice. Female Balb/c mice, inoculated with mouse breast tumor 4T1 cells, were administered with metronomic ZOL (0.0125 mg/kg twice a week for 4 weeks), or CV (1 g/kg daily for 4 weeks), or combined ZOL and CV treatments. Results showed that the final tumor weights of combined ZOL and CV treatment were the lowest among all treated groups. The combined ZOL and CV treatment significantly attenuated ZOL-induced lung metastasis. The numbers of Ki-67-positive tumor cells and CD34positive endothelial cells in tumor sections of the combined treatment group were also lower than the control. Besides, the CD4/CD8 T-lymphocytes ratio in tumor-bearing mice was increased in CV-treated (alone or with ZOL) groups. In conclusion, we reported for the first time the anti-tumor, anti-angiogenic and immunomodulatory effects of the combined ZOL and CV treatment in a metastatic breast tumor model. Acknowledgement: This work was supported by Food and Health Bureau HKSAR, Health and Medical Research Fund no. 10110891.
All Author(s) ListYue GGL, Ko CH, Gao S, Lee JKM, Kwok HF, Kung JS, Li L, Fung KP, Leung PC, Li G, Evdokiou A, Lau CBS
Name of ConferenceJoint Meeting of the GP-TCM Research Association, The TCM Chemistry Specialty Committee and The TCM Pharmaceutical Analysis Specialty Committee of the World Federation of Chinese Medicine Societies (WFCMS)
Start Date of Conference13/07/2015
End Date of Conference15/07/2015
Place of ConferenceMons
Country/Region of ConferenceBelgium
Proceedings TitleWorld Journal of Traditional Chinese Medicine
Year2015
Volume Number1
Issue Number4
Pages94
LanguagesEnglish-United Kingdom

Last updated on 2018-25-04 at 16:41