Assessing volumetric bone mineral density in adolescent idiopathic scoliosis: quantitative computed tomography vs high-resolution peripheral quantitative computed tomography - a pilot study
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Low bone mass has been reported in about 30% of girls with Adolescent Idiopathic Scoliosis (AIS). Quantitative Computed Tomography (QCT) could provide differential assessment of cortical and trabecular volumetric BMDs (vBMDs) which cannot be measured by areal DXA. However, regular assessment with QCT in adolescents is not appropriate due to high radiation exposure. High-resolution Peripheral QCT (HR-pQCT) has been used as an alternative measurement for axial vBMD. This pilot study aimed to test whether the vBMDs of distal radius measured with HR-pQCT correlate with that of lumbar spine from QCT in girls with AIS.

Subjects and Methods:
14 severe AIS girls aged 13-19 (mean age 15.4 ± 1.8) with pre-operative CT scan of the spine for planning of navigation surgery were recruited. Lumbar spine (L1-L2) and non-dominant distal radius were measured by QCT and HR-pQCT respectively. Results were analyzed with Pearson correlation.

The mean Cobb angle was 64.4 ± 12.8° (range 45-87°). Of the 14 patients, 3 (21.4%) were osteopenic with z-score of femoral neck ≤-1. Significant correlations were found between L1, L2 vertebrae and distal radius including cortical vBMD (L1: r=0.769, p=0.026; L2: r=0.550, p=0.042) and trabecular vBMD (L1: r=0.797, p=0.018; L2: r=0.645, p=0.013).

Discussion and Conclusion:
The vBMDs measured by QCT at L1 and L2 vertebrae (central skeleton) were correlated with that of HR-pQCT at non-dominant distal radius (peripheral skeleton) indicating that HR-pQCT, with very low radiation and capable of trabecular microarchitecture measurement, could be used for assessment for systemic bone quality in patients with AIS. Further studies with larger sample size would be carried out to validate the findings.
All Author(s) ListE. M. S. Tam, F. W. P. Yu, V. W. Y. Hung, L. Shi, L. Qin, B. K. W. Ng, W. C. W. Chu, J. F. Griffith, J. C. Y. Cheng, T. P. Lam
Name of Conference2016 International Combined Meeting of Orthopaedics Research Societies
Start Date of Conference21/09/2016
End Date of Conference25/09/2016
Place of ConferenceXi'an, China
Country/Region of ConferenceChina
LanguagesEnglish-United Kingdom

Last updated on 2018-22-01 at 09:17