Reduced White Matter Integrity at Splenium of Corpus Callosum Connecting to Somatosensory Cortex in Adolescent Idiopathic Scoliosis (AIS) compared with Normal Control - A Cerebral Diffusion Tensor Imaging (DTI) Study
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AbstractAbstract Body (500 words):
• Introduction:
Increasing evidences show the possibility of an underlying neurological disorder for Adolescent Idiopathic Scoliosis (AIS), such as the disturbed somatosensory functions. In this study, we examined the cerebral white matter fiber bundles in AIS using Diffusion Tensor Imaging (DTI), a Magnetic Resonance Imaging (MRI) technique to measure the white matter integrity, e.g. fiber density, and myelination in white matter reflected by the fractional anisotropy (FA). We will focus in the largest white matter fiber bundles, Corpus callosum (CC) which is acting as a bridge to link the two hemispheres of the brain (left and right) because morphological changes in CC have been reported by our group previously1.

• Subjects and Methods:
Thirty three AIS patients (girl, right thoracic curve, age 14.9 +/- 1.4) and thirty age-matched normal control (NC) (girl, age 14.7 +/- 0.9) underwent DTI along 32 non-linear directions using a 3T MRI scanner. 3D segmentation of Corpus Callosum is performed semi–automatically using ITK-SNAP 2.4, followed by regional segmentation of the CC using a well-known CC template, Witelson,et.al template.

• Results:
In the 3D segmentation, significantly lower mean FA values of the genu of the CC interconnecting the premotor cortex and splenium of the CC interconnecting somatosensory cortex were found in AIS patients compared to those in normal control (p<0.001), while the other regions also showed a lower FA value in AIS though have not yet reached statistical significance.

• Discussion and Conclusion:
Generalized lower FA values in CC of the AIS patient indicates that there is a reduced white matter integrity of CC, in particular the genu and the splenium of the CC fibers interconnecting the premotor cortex, as well as the somatosensory cortex respectively. This coincides with our clinical observation of significantly prolonged latency of Somatosensory Evoked Potentials (SSEP) over the somatosensory cortex on the side of the major curve2. Along with our previous study which showed a reduction of white matter integrity within the cervical cord3, we observe a general reduction of white matter integrity in major fibers connecting to somatosensory cortex in AIS.

• References
[1]WANG Defeng; SHI Lin; CHU Chiu Wing Winnie; PAUS Tomáš; CHENG Chun Yiu Jack and HENG Pheng Ann. "A Comparison of Morphometric Techniques for Studying the Shape of the Corpus Callosum in Adolescent Idiopathic Scoliosis". NeuroImage vol.45 no.3, p.738-748. 2009 Elsevier Inc., 2009.04.15. 2009.04.15.
[2]W.W. Chau, W.C. Chu , Lam. T.P & J.C. Cheng, "Anatomical Origin of Abnormal Somatosensory Evoked Potential (SEP) in Adolescent Idiopathic Scoliosis with Different Curve Severity and Correlation with Cerebellar Tonsillar Level Determined by MRI," Spine, Nov. 2015.
[3] Kong Y, Shi L, Hui SC, Wang D, Deng M, Chu WC, Cheng JC. Variation in anisotropy and diffusivity along medulla oblongata and the whole spinal cord in Adolescent Idiopathic Scoliosis: A pilot study using diffusion tensor imaging. AJNR Am J Neuroradiol. 2014;35 (8):1621-7. Selected as highlights in AJNR News Digest April 2015
All Author(s) ListC. Xue, L. Shi, S. C. N. Hui, T. P. Lam, B. K. W. Ng, J. C. Y. Cheng and W. C. W. Chu
Name of ConferenceInternational Combined Meeting of Orthopaedics Research Societies
Start Date of Conference21/09/2016
End Date of Conference25/09/2016
Place of ConferenceXi'an, China
Country/Region of ConferenceChina
Proceedings TitleProceedings of the 2016 International Combined Meeting of Orthopaedic Research Societies
Series TitleProceedings of the 2016 International Combined Meeting of Orthopaedic Research Societies
Number in Series225
Year2016
Month10
Volume Number7
Issue Number100-101
PublisherElsevier (Singapore) Pte Ltd.
Place of PublicationInternational
Pages100 - 100
LanguagesEnglish-United Kingdom

Last updated on 2020-29-11 at 01:46