Hydroxytetraphenylenes as Chiral Ligands: Application to Asymmetric Darzens Reaction of Diazoacetamide with Aldehydes
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Hydroxytetraphenylenes with rigid conformations are potential candidates for employment as chiral ligands in asymmetric synthesis. Highly diastereo-and enantioselective Darzens reactions between aldehydes and diazo-N, N-dimethylacetamide were found to be catalyzed by a chiral titanium complex formed in situ from Ti(OiPr)(4) and chiral 1,16-dihydroxytetraphenylene, leading to the formation of cis-glycidic amides in moderate to high yields with excellent enantiomeric purities (40-99% yield, up to 99% ee).
著者Chai GL, Han JW, Wong HNC
期刊名稱SYNTHESIS
出版年份2017
卷號49
期次1
出版社GEORG THIEME VERLAG KG
頁次181 - 187
國際標準期刊號0039-7881
語言英式英語
關鍵詞asymmetric catalysis, tetraphenylene, chiral ligand, Darzens reaction, diazoacetamide
Web of Science 學科類別Chemistry, Organic;Chemistry

上次更新時間 2020-25-10 於 02:32