FE65: Roles beyond amyloid precursor protein processing
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AbstractFE65 is a brain-enriched, developmentally regulated adaptor protein that was first identified as a binding partner of amyloid precursor protein (APP), an important molecule in Alzheimer's disease. FE65 possesses three protein interaction domains, including an N-terminal WW domain and two C-terminal phosphotyrosine-binding (PTB) domains. It is capable of mediating the assembly of multimolecular complexes. Although initial work reveals its roles in APP processing and gene transactivation, increasing evidence suggests that FE65 participates in more diverse biological processes than originally anticipated. This article discusses the role of FE65 in signal transduction during cell stress and protein turnover through the ubiquitin-proteasome system and in various neuronal processes, including neurogenesis, neuronal migration and positioning, neurite outgrowth, synapse formation and synaptic plasticity, learning, and memory.
All Author(s) ListChow W.N.V., Cheung H.N.M., Li W., Lau K.-F.
Title of PublicationFE65: Roles beyond amyloid precursor protein processing
Year2015
Month1
Day1
Volume Number20
Issue Number1
PublisherWalter de Gruyter GmbH
Place of PublicationGermany
Pages66 - 87
ISSN1689-1392
LanguagesEnglish-United Kingdom
KeywordsCell stress, FE65, Learning and memory, Neurite outgrowth, Neurogenesis, Neuronal migration and positioning, Protein turnover, Synapse formation and synaptic plasticity

Last updated on 2020-30-06 at 04:11