FE65: Roles beyond amyloid precursor protein processing
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其它資訊
摘要FE65 is a brain-enriched, developmentally regulated adaptor protein that was first identified as a binding partner of amyloid precursor protein (APP), an important molecule in Alzheimer's disease. FE65 possesses three protein interaction domains, including an N-terminal WW domain and two C-terminal phosphotyrosine-binding (PTB) domains. It is capable of mediating the assembly of multimolecular complexes. Although initial work reveals its roles in APP processing and gene transactivation, increasing evidence suggests that FE65 participates in more diverse biological processes than originally anticipated. This article discusses the role of FE65 in signal transduction during cell stress and protein turnover through the ubiquitin-proteasome system and in various neuronal processes, including neurogenesis, neuronal migration and positioning, neurite outgrowth, synapse formation and synaptic plasticity, learning, and memory.
著者Chow W.N.V., Cheung H.N.M., Li W., Lau K.-F.
出版作品名稱FE65: Roles beyond amyloid precursor protein processing
出版年份2015
月份1
日期1
卷號20
期次1
出版社Walter de Gruyter GmbH
出版地Germany
頁次66 - 87
國際標準期刊號1689-1392
語言英式英語
關鍵詞Cell stress, FE65, Learning and memory, Neurite outgrowth, Neurogenesis, Neuronal migration and positioning, Protein turnover, Synapse formation and synaptic plasticity

上次更新時間 2021-23-10 於 23:29