Mesenchymal stern cell intracellular labeling using silica-coated superparamagnetic iron oxide nanoparticles with amine functional peripheries
Refereed conference paper presented and published in conference proceedings

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摘要Two types of superparamagnetic iron oxide nanoparticles designed for mesenchymal stem cell labeling and magnetic resonance imaging in vivo tracking were constructed in our laboratories. Both types of nanoparticles have an iron oxide core and a thin layer of silica coating, one of them has additional surface modification with amine. The overall particle size was around 8 nanometers. The in vitro study results demonstrated that, without the application of a transfection agent, both nanoparticles could be incorporated into bone marrow derived mesenchymal stem cells and located in lysosomes. Surface modification with amine significantly increased mesenchymal stem cell labeling efficiency, leading to an increased magnetic resonance imaging detection sensitivity of 2-5 folds. © 2008 IEEE.
著者Wang H.-H., Wang Y.-X.J., Leung K.C.-F., Sheng H., Zhang G., Lee S.K.M., Au D.W.T., Chak C.-P., Qin L., Griffith J.F.
會議名稱5th International Conference on Information Technology and Applications in Biomedicine, ITAB 2008 in conjunction with 2nd International Symposium and Summer School on Biomedical and Health Engineering, IS3BHE 2008
會議開始日30.05.2008
會議完結日31.05.2008
會議地點Shenzhen
會議國家/地區中國
詳細描述organized by Institute of Biomedical and Health Engineering,
出版年份2008
月份9
日期22
頁次187 - 189
國際標準書號9781424422555
語言英式英語
關鍵詞Magnetic resonance imaging, Molecular imaging, Nanoparticles, Stem cell

上次更新時間 2020-07-08 於 23:38