Targeting tail-anchored proteins into plant organelles
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AbstractThe extensive evolution of intracellular compartmentalization requires highly selective mechanisms for protein targeting to distinct membrane systems. One of the fundamental processes in protein targeting is the insertion of proteins into biological membranes. The efficient and accurate insertion of membrane proteins is an important step for their proper function in different organelles, and any targeting error may lead to mislocalization of these proteins with detrimental cellular effects. Posttranslational insertion is required for a class of tail-anchored (TA) proteins, which are characterized by a transmembrane domain (TMD) near their C terminus, for their correct targeting to the destined membrane (1). In PNAS, Xing et al. uncover a pathway for TA protein insertion into the endoplasmic reticulum (ER) in the model plant Arabidopsis thaliana, which plays an unexpected role in root hair growth (2). The authors identify several key components in the guided entry of tail-anchored protein (GET) complex that has a conserved function in regulating TA protein insertion. However, in contrast to yeast and animals, the core GET system in Arabidopsis involves a distinct GET3 clade, suggesting an ancient evolution of the GET3 paralogs in plants and which may function divergently as plant-specific organelle chaperones.
All Author(s) ListXiaohong Zhuang, Kin Pan Chung, Liwen Jiang
Journal nameProceedings of the National Academy of Sciences
Year2017
Month2
Day21
Volume Number114
Issue Number8
Pages1762 - 1764
ISSN0027-8424
LanguagesEnglish-United Kingdom

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