Reduced White Matter Integrity at Splenium of Corpus Callosum Connecting to Somatosensory Cortex in Adolescent Idiopathic Scoliosis (AIS) compared with Normal Control - A Cerebral Diffusion Tensor Imaging (DTI) Study
Other conference paper


摘要Introduction: Possibilities of an underlying neurological disorder, such as the disturbed somatosensory functions, in
adolescent idiopathic scoliosis (AIS) have been studied rigorously. In this study, we used diffusion tensor imaging (DTI), a magnetic resonance imaging (MRI) technique to measure the cerebral white matter fibre bundles in AIS as DTI could measure the white matter integrity, e.g. fibre density, and myelination in white matter reflected by fractional anisotropy (FA). We focused in the corpus callosum being the largest white matter fibre bundles, and morphological change detected in previous study.

Methods: A total of 33 AIS patients (girl, right thoracic curve, mean [± standard deviation] age, 14.9 ± 1.4 years) and 30 age-matched normal controls (girl, mean age 14.7 ± 0.9 years) underwent DTI along 32 non-linear directions using a 3 Tesla magnetic resonance image scanner. Three-dimensional segmentation of corpus callosum (CC) was performed semiautomatically using ITK-SNAP 2.4, followed by regional segmentation of the CC using Witelson et al’s template.

Results: Three-dimensional segmentation analysis showed significantly lower mean FA values in genu of CC, and in
splenium of CC compared with those in normal controls (p<0.001). Other regions also showed lower FA values in AIS
despite not reaching statistical significance.

Discussion and Conclusion: Generalised lower FA values in CC in AIS indicates reduced white matter integrity of CC, in particular genu and splenium of CC interconnecting premotor cortex and somatosensory cortex, respectively. This finding coincides with our clinical observation of significantly prolonged latency of somatosensory evoked potentials over the somatosensory cortex on the side of the major curve.
著者C. Xue, L. Shi, S. C. N. Hui, T. P. Lam, J. C. Y. Cheng and W. C. W. Chu
會議名稱The 36th Annual Congress of the Hong Kong Orthopaedic Association (HKOA)
會議地點Hong Kong

上次更新時間 2018-22-01 於 09:16