Evaluating the Relationships between Body Composition, Muscle Strength, and Bone Quality Parameters in Girls with Adolescent Idiopathic Scoliosis
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摘要Introduction: Muscle exerts dynamic mechanical loads to promote bone formation, and decrease in muscle mass was
shown to be linked to osteoporosis. The deranged bone quality associated with adolescent idiopathic scoliosis (AIS) could be contributed by low muscle mass. This study aimed to investigate the correlations between body composition, grip strength, and bone quality parameters in AIS versus controls.

Methods: A total of 183 AIS girls aged 12 to 14 years with different curve severity (Cobb’s angle of 10°-72°) and 169 agematched control girls were recruited. Skeletal muscle mass (SMM), fat-free mass (FFM), and body fat mass (BFM) were measured with bioelectrical impedance analysis. Grip strength of both hands were measured by dynamometer. Bilateral femoral neck bone mineral densities (FNBMDs) and non-dominant distal radius were measured by dual-energy X-ray absorptiometry and high-resolution peripheral quantitative computed tomography, respectively.

Results: Girls with AIS had lower SMM, FFM, BFM, grip strength, bilateral FNBMDs, mean volumetric bone mineral
density (vBMD), and cortical bone parameters (vBMD, thickness, area) compared with controls. In correlations with bone quality parameters, AIS group showed generally weaker correlations with SMM and stronger correlations with BFM after adjustment for age and arm span. Multiple linear regression showed that correlations between BFM and FNBMDs were significantly different between AIS and controls, while correlations between SMM, non-dominant FNBMD, and grip strength were marginal (p<0.1).

Conclusion: This study provided some evidence that bone in AIS girls could respond differently to biochemical and
mechanical stimuli exerted by muscle and adipose tissues. Study into fat-bone and muscle-bone interactions could provide more in-depth understanding on the aetiology of low bone mass in AIS.
著者E. M. S. Tam, F. W. P. Yu, V. W. Y. Hung, L. Qin, J. C. Y. Cheng, T. P. Lam
會議名稱The 36th Annual Congress of the Hong Kong Orthopaedic Association (HKOA)
會議開始日05.11.2016
會議完結日06.11.2016
會議地點Hong Kong
會議國家/地區香港
出版年份2016
語言英式英語

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