Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要MAE-W is a favorable method for the preparation of HQ extracts based on extraction yield, pharmacological properties and safety.
The HQ extraction efficiency by MAE-W was the best. The chemical profiles of extracts obtained using HRE-W and MAE-W were similar; whereas more flavones but less flavone glycosides were detected in the UE-E extract. There was no difference in the antioxidant properties among different extracts. In vitro human liver microsome assays illustrated that all extracts possessed herb-drug interaction potentials but the UE-E extract are shown with a potent interaction with CYP3A4-metabolized drugs.
This study reported a comprehensive approach (comparing the extraction yields, chemical profiles, antioxidant properties and CYP450-inhibitory effects) to evaluated the effectiveness of various extraction methods [microwave-assisted extraction using water (MAE-W), heat reflux extraction using water (HRE-W), ultrasonic extraction using 70 % ethanol and ultrasonic extraction using ethanol (UE-E)] for Huang-Qin (HQ), the dried root of Scutellaria baicalensis Georgi.
著者Xuelin Zhou, Pou Seng Choi, Jia-Ming Yang, Penelope M. Y. Or, Pui Man Hoi, Simon M. Y. Lee, George P. H. Leung, Sai Ming Ngai, Siu Kai Kong, Ho Pui Ho, Melody Y. M. Wong, Shun Wan Chan, John H. K. Yeung, Yiu Wa Kwan
期刊名稱Springerplus
出版年份2016
月份8
日期30
卷號5
出版社Springer
頁次1438
國際標準期刊號2193-1801
語言英式英語
關鍵詞Scutellaria baicalensis Georgi, Extraction efficiency, Antioxidant properties, Herb–drug interaction

上次更新時間 2020-21-09 於 01:55