Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods
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AbstractMAE-W is a favorable method for the preparation of HQ extracts based on extraction yield, pharmacological properties and safety.
The HQ extraction efficiency by MAE-W was the best. The chemical profiles of extracts obtained using HRE-W and MAE-W were similar; whereas more flavones but less flavone glycosides were detected in the UE-E extract. There was no difference in the antioxidant properties among different extracts. In vitro human liver microsome assays illustrated that all extracts possessed herb-drug interaction potentials but the UE-E extract are shown with a potent interaction with CYP3A4-metabolized drugs.
This study reported a comprehensive approach (comparing the extraction yields, chemical profiles, antioxidant properties and CYP450-inhibitory effects) to evaluated the effectiveness of various extraction methods [microwave-assisted extraction using water (MAE-W), heat reflux extraction using water (HRE-W), ultrasonic extraction using 70 % ethanol and ultrasonic extraction using ethanol (UE-E)] for Huang-Qin (HQ), the dried root of Scutellaria baicalensis Georgi.
All Author(s) ListXuelin Zhou, Pou Seng Choi, Jia-Ming Yang, Penelope M. Y. Or, Pui Man Hoi, Simon M. Y. Lee, George P. H. Leung, Sai Ming Ngai, Siu Kai Kong, Ho Pui Ho, Melody Y. M. Wong, Shun Wan Chan, John H. K. Yeung, Yiu Wa Kwan
Journal nameSpringerplus
Volume Number5
LanguagesEnglish-United Kingdom
KeywordsScutellaria baicalensis Georgi, Extraction efficiency, Antioxidant properties, Herb–drug interaction

Last updated on 2021-13-05 at 03:02