Abnormal Bone Metabolism in Adolescent Idiopathic Scoliosis? A Study of the Association of Serum Bone Turnover Markers with Bone Mineral Density and Bone Quality in Adolescent Idiopathic Scoliosis Versus Controls
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摘要Introduction: Low bone mineral density was found in over 30% of adolescent idiopathic scoliosis (AIS) with few studies on serum bone turnover markers. This study aimed to correlate the serum level of key bone turnover markers with advanced bone quality parameters in AIS compared with normal controls.

Methods: The Institutional Review Board–approved case-control study included 50 AIS girls (mean [± standard deviation] Cobb’s angle, 32.7° ± 17.9°) and 35 age- and gender-matched controls. Bone quality parameters were measured with dualenergy X-ray absorptiometry and high-resolution peripheral quantitative computed tomography with added individual trabecula segmentation (ITS) analysis technique. Serum levels of osteocalcin, osteopontin, osteoprotegerin, parathyroid hormone (PTH), dickkopf-related protein 1, and sclerostin were measured with multiplex array.

Results: The mean age of AIS and control subjects were 13.7 and 14.3 years, respectively. Comparing with normal controls, AIS group showed lower body weight and body mass index with significantly lower areal bone mineral density, cortical and trabecular volumetric bone mineral density associated with lower cortical area, cortical thickness, and trabecular area. Advanced ITS also revealed lower trabecular plate BV/TV (bone volume fraction) and connectivity density in AIS. The AIS group had significantly higher serum osteocalcin level (31.1% difference) and higher level of sclerostin, PTH, and osteopontin with abnormal correlation with the bone parameters as compared with the controls.

Conclusion: This is the first study demonstrating the abnormal bone quality and microstructure in AIS with associated
abnormal key bone turnover markers pointing to underlying abnormal bone metabolism and possible related dysfunction of the bone cells. Further validation studies with larger cohorts with different severities and in-depth mechanistic study will be warranted.
著者HX Chen, WYW Lee, JJ Zhang, EMS Tam, FWP Yu, JCY Cheng
會議名稱The 36th Annual Congress of the Hong Kong Orthopaedic Association (HKOA)
會議地點Hong Kong

上次更新時間 2018-22-01 於 09:15