The relationship between angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism, serum ACE activity and bone mineral density (BMD) in older Chinese
Publication in refereed journal


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摘要Objective: In this study, we set out to investigate the relationship between angiotensin-converting enzyme (ACE) I/D polymorphism, serum ACE activity and bone mineral density (BMD) in older Chinese.Methods: A standardized, structured, face-to-face interview was performed to collect demographic information. BMD was measured using dual-energy X-ray absorptiometry (DXA). I/D genotypes of ACE were determined by polymerase chain reaction (PCR) amplification. Serum ACE activity was determined photometrically by a commercially available kinetic kit. Multiple linear regression analysis was used to examine the relationship between ACE I/D polymorphism, serum ACE activity and BMD.Results: A total of 1567 males and 1760 females were selected for analyzing the relationship between ACE I/D polymorphism and BMD. There was no significant difference in spine BMD, total hip BMD and femur neck BMD among different ACE I/D genotypes both in males and females. A total of 1699 males and 1739 females were selected for analyzing the relationship between serum ACE activity and BMD. There was also no significant difference in spine BMD, total hip BMD and femur neck BMD among different serum ACE activity groups both in males and females.Conclusion: There was no relationship between ACE I/D polymorphism, serum ACE activity and BMD in older Chinese.
出版社接受日期01.01.2017
著者Zhang YF, Wang H, Cheng Q, Qin L, Tang NLS, Leung PC, Kwok TCY
期刊名稱Journal of the Renin-Angiotensin-Aldosterone System
出版年份2017
卷號18
期次1
出版社SAGE PUBLICATIONS LTD
頁次1 - 7
國際標準期刊號1470-3203
電子國際標準期刊號1752-8976
語言英式英語
關鍵詞Angiotensin-converting enzyme,I/D polymorphism,serum ACE activity,bone mineral density,Chinese
Web of Science 學科類別Peripheral Vascular Disease;Cardiovascular System & Cardiology

上次更新時間 2020-08-08 於 02:48