Cathelicidin protects against intestinal barrier dysfunction in polymicrobial sepsis
Refereed conference paper presented and published in conference proceedings


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摘要Accumulating evidence suggests that the intestinal barrier function is impaired during systemic inflammation as in sepsis. Animal models of sepsis revealed several ileal pathological changes. These include epithelial apoptosis, disruption of tight junctions and increased intestinal permeability [1,2]. The impaired gut barrier function may increase the risk of bacterial translocation from the gut lumen to the bloodstream, aggravating systemic inflammation. The molecular mechanism associated with this phenotype remains largely unknown. Cathelicidin represents one of the most important classes of antimicrobial peptides in mammals. In addition to bactericidal property, this peptide inhibits endotoxin-induced pyroptosis of leukocytes, suppresses the release of inflammatory mediators and protects endothelial cells from apoptosis [3–5]. In this study, we aimed to investigate the role of murine cathelicidin-related antimicrobial peptide (mCRAM), a rodent antimicrobial peptide analogous to human LL-37, in maintaining gut barrier function in sepsis.
著者Ho J, Liu XD, Kwong T, Zhang L, Chan H, Wong SH, Choi G, Gin T, Chan MTV, Wu WKK.
會議名稱Sepsis 2016 Paris
會議開始日06.12.2016
會議完結日08.12.2016
會議地點Paris
會議國家/地區法國
期刊名稱Critical Care
會議論文集題名Critical care
出版年份2016
月份12
日期6
卷號20
期次Suppl. 3
出版社BioMed Central
頁次189 - 191
國際標準期刊號1466-609X
電子國際標準期刊號1364-8535
語言美式英語

上次更新時間 2021-18-01 於 00:58