Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi
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摘要Melodinine V (1) with a vincanol-eburenine skeleton, was isolated from Melodinus henryi. The structure was elucidated by extensive spectroscopic methods and further confirmed by the single crystal X-ray diffraction analysis. Melodinine V showed selective cytotoxic activities against human colon cancer cell line HT-29 and inhibited cell proliferation in a concentration-dependent manner. It induced cell cycle arrest at G1 phase and cellular apoptosis by increasing histone-associated DNA fragmentation in the treated HT-29 cells.
著者Liu YP, Yue GGL, Lee JKM, Feng T, Zhao YL, Li Y, Lau CBS, Luo XD
期刊名稱Bioorganic and Medicinal Chemistry Letters
出版年份2016
月份10
日期15
卷號26
期次20
出版社PERGAMON-ELSEVIER SCIENCE LTD
頁次4895 - 4898
國際標準期刊號0960-894X
電子國際標準期刊號1464-3405
語言英式英語
關鍵詞Melodinine V,Bisindole,Inhibited cell proliferation,Cell cycle arrest,Cellular apoptosis,HT-29 cells
Web of Science 學科類別Chemistry, Medicinal;Chemistry, Organic;Pharmacology & Pharmacy;Chemistry

上次更新時間 2021-17-01 於 01:23