Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi
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AbstractMelodinine V (1) with a vincanol-eburenine skeleton, was isolated from Melodinus henryi. The structure was elucidated by extensive spectroscopic methods and further confirmed by the single crystal X-ray diffraction analysis. Melodinine V showed selective cytotoxic activities against human colon cancer cell line HT-29 and inhibited cell proliferation in a concentration-dependent manner. It induced cell cycle arrest at G1 phase and cellular apoptosis by increasing histone-associated DNA fragmentation in the treated HT-29 cells.
All Author(s) ListLiu YP, Yue GGL, Lee JKM, Feng T, Zhao YL, Li Y, Lau CBS, Luo XD
Journal nameBioorganic and Medicinal Chemistry Letters
Year2016
Month10
Day15
Volume Number26
Issue Number20
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Pages4895 - 4898
ISSN0960-894X
eISSN1464-3405
LanguagesEnglish-United Kingdom
KeywordsMelodinine V,Bisindole,Inhibited cell proliferation,Cell cycle arrest,Cellular apoptosis,HT-29 cells
Web of Science Subject CategoriesChemistry, Medicinal;Chemistry, Organic;Pharmacology & Pharmacy;Chemistry

Last updated on 2021-02-03 at 03:06