Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi
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AbstractMelodinine V (1) with a vincanol-eburenine skeleton, was isolated from Melodinus henryi. The structure was elucidated by extensive spectroscopic methods and further confirmed by the single crystal X-ray diffraction analysis. Melodinine V showed selective cytotoxic activities against human colon cancer cell line HT-29 and inhibited cell proliferation in a concentration-dependent manner. It induced cell cycle arrest at G1 phase and cellular apoptosis by increasing histone-associated DNA fragmentation in the treated HT-29 cells.
All Author(s) ListLiu YP, Yue GGL, Lee JKM, Feng T, Zhao YL, Li Y, Lau CBS, Luo XD
Journal nameBioorganic and Medicinal Chemistry Letters
Volume Number26
Issue Number20
Pages4895 - 4898
LanguagesEnglish-United Kingdom
KeywordsMelodinine V,Bisindole,Inhibited cell proliferation,Cell cycle arrest,Cellular apoptosis,HT-29 cells
Web of Science Subject CategoriesChemistry, Medicinal;Chemistry, Organic;Pharmacology & Pharmacy;Chemistry

Last updated on 2021-02-03 at 03:06