Biodegradable magnesium screws accelerate fibrous tissue mineralization at the tendon-bone insertion in anterior cruciate ligament reconstruction model of rabbit
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要The incorporation of tendon graft into bone tunnel is one of the most challenging clinical issues in anterior cruciate ligament (ACL) reconstruction. As a biodegradable metal, Mg has appropriate mechanical strength and osteoinductive effects, thus may be a promising alternative to commercialized products used for graft fixation. Therefore, it was hypothesized that Mg based interference screws would promote tendon graft-bone junction healing when compared to Ti screws. Herein, we compared the effects of Mg and Ti screws on tendon graft healing in rabbits with ACL reconstruction via histological, HR-pQCT and mechanical analysis. The histological results indicated that Mg screws significantly improved the graft healing quality via promoting mineralization at the tendon graft enthesis. Besides, Mg screws significantly promoted bone formation in the peri-screw region at the early healing stage. Importantly, Mg screws exhibited excellent corrosion resistance and the degradation of Mg screws did not induce bone tunnel widening. In tensile testing, there were no significant differences in the load to failure, stress, stiffness and absorption energy between Mg and Ti groups due to the failure mode at the midsubstance. Our findings demonstrate that Mg screws can promote tendon graft healing after ACL reconstruction, implying a potential alternative to Ti screws for clinical applications.
出版社接受日期06.12.2016
著者Jiali Wang, Jiankun Xu, Weimin Fu, Wenxiang Cheng, Kaiming Chan, Patrick Shu-hang Yung, Ling Qin
期刊名稱Scientific Reports
詳細描述Article number: 40369
出版年份2017
月份1
日期10
卷號7
出版社Nature.com
國際標準期刊號2045-2322
電子國際標準期刊號2045-2322
語言美式英語

上次更新時間 2021-19-02 於 00:27