Optimisation of platelet concentrates therapy: Composition, localisation, and duration of action
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AbstractPlatelet concentrates (PC) generally refers to a group of products that are prepared from autologous blood intended to enhance healing activities. PC therapy is now very popular in treating musculoskeletal injuries; however, inconsistent clinical results urge the need to understand the working mechanism of PC. It is generally believed that the platelet-derived bioactive factors are the active constituents, and their bioavailability in the vicinity of the lesion sites determines the treatment efficacies. Therefore, the composition, localisation, and duration of the action of PC would be key determinants. In this review, we discuss how different preparations and delivery methods of PC would affect the treatment outcomes with respect to clinical evidence about PC therapy for osteoarthritis, tendinopathies, rotator cuff tears, anterior cruciate ligament injuries, and bone fractures. This review can be used as a quick guide for the use of PC therapy and provide insights for the further optimisation of the therapy in the near future.
Acceptance Date29/11/2016
All Author(s) ListYuk-Lin Yung, Sai-Chuen Fu, Yau-Chuk Cheuk, Ling Qin, Michael Tim-Yun Ong, Kai-Ming Chan, Patrick Shu-Hang Yung
Journal nameAsia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology
Volume Number7
PublisherElsevier (Singapore) Pte Ltd
Place of PublicationSingapore
Pages27 - 36
LanguagesEnglish-United States
Keywordscomposition, duration, localisation, platelet concentrates, platelet-rich plasma

Last updated on 2020-04-06 at 00:27