Epstein-barr virus diagnostic and therapeutic opportunities in nasopharyngeal carcinoma
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AbstractEpstein-Barr virus (EBV) is a ubiquitous g herpes virus that infects over 90% of the world's population. After an initial lytic phase of infection in humans where virions are released, the virus persists in a small proportion of B lymphocytes in a latent state. The episomal latent virus has oncogenic potential and has been implicated in the pathogenesis of many malignancies, including nasopharyngeal carcinoma (NPC), gastric carcinoma and a variety of lymphoproliferative disorders.Amongthesemalignancies,theassociationbetween EBV and NPC is one of the strongest. The undifferentiated nonkeratinizing subtype of NPC, commonly seen in South China and Hong Kong, is almost universally associated with type II EBV latency. In addition to viral integration into the host genome that modulates gene expression, aberrant serum immune responses to EBV are also seen in these patients. The universal presence of episomal clonal EBV in tumor tissue and the associated atypical host immune responses have been exploited for diagnostic and therapeutic purposes in this disease.
All Author(s) ListRaghupathy R., Hui E.P., Chan A.T.C.
Year2014
Month8
Day1
Pages167 - 187
ISBN9781780843933
LanguagesEnglish-United Kingdom

Last updated on 2020-19-09 at 04:09