Association between sleep architecture and glucose tolerance in children and adolescents
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AbstractBackground: Short sleep duration is a contributing factor for decreased insulin sensitivity and hyperglycemia. Sleep architecture represents a cyclical pattern of sleep that shifts between sleep Stages N1, N2, N3 (slow wave sleep) and Stage R (rapid eye movement sleep). The aim of the present study was to examine the association between sleep architecture and glucose and insulin metabolism in both normal weight and overweight/obese children and adolescents. Methods: A total of 118 subjects participated in the study. Subjects underwent overnight polysomnography (PSG) when the percentage of total sleep time (% TST) spent at each sleep stage was recorded and an oral glucose tolerance test together was performed the next morning. We assessed glucose tolerance, insulin sensitivity and pancreatic β-cell function using 2-h glucose levels, the Matsuda index (ISOGTT), and insulin secretion-sensitivity index-2 (ISSI-2), respectively. Results: After adjustment for age, gender, body mass index z-score, pubertal status, and obstructive apnea hypopnea index, Stage N3 (% TST) was positively associated with ISOGTT, whereas Stage N1 (%TST) exerted an opposite effect on ISOGTT. Higher sleep efficiency and longer TST were independently associated with lower 2-h glucose levels, higher ISSI-2 and/or higher ISOGTT. Conclusions: Stage N3, sleep efficiency and TST were protective factors in maintaining glucose and insulin homeostasis; however, Stage N1 functioned in the opposite direction.
All Author(s) ListZhu Y., Li A.M., Au C.T., Kong A.P.S., Zhang J., Wong C.K., Chan J.C.N., Wing Y.K.
Journal nameJournal of Diabetes
Year2015
Month1
Day1
Volume Number7
Issue Number1
PublisherBlackwell Publishing Asia Pty Ltd
Place of PublicationAustralia
Pages10 - 15
ISSN1753-0393
LanguagesEnglish-United Kingdom
KeywordsChildren, Glucose tolerance, Insulin sensitivity, Sleep architecture, Sleep stage

Last updated on 2020-10-08 at 02:07