Outcome of Encephalitis in Pediatric Intensive Care Unit
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AbstractObjective: To review pathogens, morbidity and mortality in pediatric intensive care unit (PICU) patients with viral and infectious encephalitis. Methods: Retrospective chart review of all patients with encephalitis admitted to the PICU between 2002 and 2014 was done. Results: Encephalitis (n = 46) accounted for 2.7 % of PICU admissions, but 11.8 % PICU mortality over a 12-y period. A microorganism (primarily virus) was identified in 59 % of encephalitis patients in the PICU. Enteroviruses and herpes viruses were isolated from the cerebrospinal fluid (CSF). Respiratory viruses [such as respiratory syncytial virus (RSV) and influenza viruses] and enteric viruses (such as rotavirus and norovirus) were obtained in the nasopharyngeal aspirate and stool respectively, but undetectable from the CSF. More than one-fourth patients with encephalitis died in the PICU. Boys accounted for 85 % of nonsurvivors and 52 % survivors (p = 0.038). Mechanical ventilation, inotrope, intravenous immunoglobulin (IVIG) and corticosteroid usage were significantly higher among non-survivors (p 0.001–0.044). Binomial logistic regression showed that patients who received corticosteroid had a lower chance of survival than those who did not after adjusting for gender, IVIG and mechanical ventilation (adjusted odd ratio = 0.071, 95 % CI 0.006-0.881; p 0.039). Eighteen (55 %) of the survivors had moderate-to-severe neurodevelopmental impairments. Conclusions: Encephalitis is associated with significant mortality despite intensive care. Over 25 % case died and 55 % of survivors had moderate-to-severe neurodevelopmental impairments. There appeared to be no emerging outbreaks of encephalitis during the 15-y study period.
All Author(s) ListHon K.-L.E., Tsang Y.C.K., Chan L.C.N., Tsang H.W., Wong K.Y.K., Wu Y.H.G., Chan P.K.S., Cheung K.L., Ng E.Y.K., Totapally B.R.
Journal nameIndian Journal of Pediatrics
Volume Number83
Issue Number10
PublisherIndian Journal of Pediatrics
Place of PublicationIndia
Pages1098 - 1103
LanguagesEnglish-United Kingdom
KeywordsEncephalitis, Enteric virus, Enterovirus, Herpes virus, Morbidity, Mortality, PICU, Respiratory virus

Last updated on 2020-19-10 at 01:29