Lipid metabolism in cartilage development, degeneration, and regeneration
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AbstractLipids affect cartilage growth, injury, and regeneration in diverse ways. Diet and metabolism have become increasingly important as the prevalence of obesity has risen. Proper lipid supplementation in the diet contributes to the preservation of cartilage function, whereas excessive lipid buildup is detrimental to cartilage. Lipid metabolic pathways can generate proinflammatory substances that are crucial to the development and management of osteoarthritis (OA). Lipid metabolism is a complicated metabolic process involving several regulatory systems, and lipid metabolites influence different features of cartilage. In this review, we examine the current knowledge about cartilage growth, degeneration, and regeneration processes, as well as the most recent research on the significance of lipids and their metabolism in cartilage, including the extracellular matrix and chondrocytes. An in-depth examination of the involvement of lipid metabolism in cartilage metabolism will provide insight into cartilage metabolism and lead to the development of new treatment techniques for metabolic cartilage damage.
All Author(s) ListZhanpeng Su, Zhixian Zong, Jinxia Deng, Jianping Huang, Guihua Liu, Bo Wei, Liao Cui, Gang Li, Huan Zhong, Sien Lin
Journal nameNutrients
Year2022
Month10
Volume Number14
Issue Number19
Article number3984
ISSN2072-6643
LanguagesEnglish-United States
