PH-responsive polymer-drug conjugates: Design and progress
Publication in refereed journal

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其它資訊
摘要Polymer-drug conjugates are becoming established as a shining platform for drug delivery. Incorporation of pH-responsive linker between drug and polymer is expected to realize triggered release of bioactive agents from conjugates in specific sites, either in mildly acidic extracellular matrices of tumor tissues or, after cellular internalization, in acidic endosomes and lysosomes. As an emerging drug delivery system, such pH-responsive polymer-drug conjugates are able to selectively deliver and activate drug molecules while reducing their systemic side-effects. In this review, we present the recent advances in pH-responsive polymer-drug conjugates with different chemical structures and architectures, and attempt to clarify their mechanism of action, synthesis and characterization technology. Furthermore, several promising approaches for the future will also be suggested.
著者Pang X., Jiang Y., Xiao Q., Leung A.W., Hua H., Xu C.
期刊名稱Journal of Controlled Release
出版年份2016
月份1
日期28
卷號222
出版社Elsevier BV
出版地Netherlands
頁次116 - 129
國際標準期刊號0168-3659
電子國際標準期刊號1873-4995
語言英式英語
關鍵詞Drug delivery system, pH-responsive, Polymer-drug conjugates, Tumor targeting

上次更新時間 2020-09-08 於 03:42