Antimicrobial activities of casein and other milk proteins
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AbstractMilk contains a variety of proteins with important biological activities. Many of them including casein, lactoferrin,alpha-lactalbumin and beta-lactoglobulin possess antimicrobial activities either in the native state or after chemical modification. Alpha(S2)-casein and alpha-lactalbumin acquire anti-HIV activity after modification with3-hydroxyphthalic anhydride Casein, alpha-lactalbumin, and beta-lactoglobulin inhibit HIV-1 protease and integrase to an appreciable extent but do not affect HIV-1 reverse transcriptase. Milk proteins (casein and beta-lactoglobulin) other than bovine lactoferrin do not prevent hepatitis C infection, Methylated or ethylated beta-casein alpha-lactalbumin and beta-lactoglobulin exert an antiviral action against bacteriophage M13, proportional to the extent of esterification and, hence, to the increased basicity of the modified proteins The tri-, tetra-, and pentaphosphorylated forms of human betacasein inhibit H. influenzae ,a pathogen implicated in middle ear infection in infants. Kappa-casein inhibits Helicobacter pylori adhesion to gastric mucosa.Lactoferrin and its fragments lactoferricin and lactoferrampin manifest inhibitory activity against a large number of viruses, bacteria and fungi. © 2011 Nova Science Publishers, Inc. All rights reserved.
All Author(s) ListNg T.B., Wong J.H., Almahdy O., El-Fakharany E.M., El-Dabaa E., Redwan E.-R.M.
All Editor(s) Listed. by Anthony M. Ventimiglia and J.M. Birkenhager.
Detailed descriptioned. by Anthony M. Ventimiglia and J.M. Birkenhager.\n\nTo ORKTS: ISBN: 9781621001294
Pages233 - 241
LanguagesEnglish-United Kingdom

Last updated on 2022-14-01 at 00:33