Transcriptional and epigenetic regulation of human microRNAs
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AbstractMicroRNAs (miRNAs) are members of non-coding RNAs. They are involved in diverse biological functions. MiRNAs are precisely regulated in a tissue- and developmental-specific manner, but dysregulated in many human diseases, in particular cancers. Transcriptional regulation, post-transcriptional regulation, as well as genetic alterations, are the three major mechanisms controlling the spatial and temporal expression of miRNAs. Emerging evidence now indicates that transcriptional and epigenetic regulations play major roles in miRNA expression. This review summarizes the current knowledge and discusses the future challenges. © 2012 Elsevier Ireland Ltd.
All Author(s) ListWang Z., Yao H., Lin S., Zhu X., Shen Z., Lu G., Poon W.S., Xie D., Lin M.C.-M., Kung H.-F.
Title of PublicationTranscriptional and epigenetic regulation of human microRNAs
Detailed descriptionTo ORKTS: doi: 10.1016/j.canlet.2012.12.006
Volume Number331
Issue Number1
PublisherElsevier BV
Place of PublicationNetherlands
Pages1 - 10
LanguagesEnglish-United Kingdom
KeywordsCancer, Epigenetic regulation, MiRNA, Transcription machinery, Transcriptional regulation

Last updated on 2020-01-07 at 02:17