Developing an effective health supplement for the prevention of osteoporosis
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AbstractThis study was carried out to investigate the effects of a bone health supporting medicinal herb formula, Herba Epimedii (E), Fructus Ligustri Lucidi (L) and Fructus Psoraleae (L)-(ELP), in maintaining bone mineral density. Laboratory models and a clinical trial were set up to study the mechanistic actions and clinical effectiveness of the herbal formula -ELF. In the in vitro studies, ELP on bone metabolism were accessed by three cell lines (UMR-106, MSCs, RAW264.7). In the in vivo studies, ovariectomised and calcium deficiency-induced osteoporotic rats were used to test the bone mineral density changes with ELP. A randomized placebo-controlled clinical trial was conducted to measure the mineral density change in post-menopausal women at the spine, femoral and tibial regions, quality of life and safety. In vitro tests using different cell lines yielded positive bone supporting results. In vivo tests using ovariectomised rats gave good evidences of bone protection. In the clinical trial, one hundred and fifty postmenopausal osteoporosis women were recruited, randomised and allocated to a herbal group (ELF) or placebo group. After 12 months of treatment using the herbal formula, there was a clear trend of BMD increase in the ELP groups although there was no statistical significance. A subgroup of women having more than 10 years' menopause gave the best results (p<0.05). The distal tibia peripheral quantitative computed tomography (pQCT) was also measured and showed a decrease of 2.43% in the herbal group compared with 3.67% in the placebo group (p = 0.05). No significant adverse effects were found. While laboratory tests demonstrated positive effects on bone metabolism in both in vitro and in vivo platforms, the clinical trial also showed the ELP help to maintain a BMD balance. ELP could be recommended as a safe preventive agent against osteoporosis. © 2012 Asian Network for Scientific Information.
All Author(s) ListLeung P.C., Ko E.C.H., Siu S.W.S., Pang E.S.Y., Wong E.L.Y., Cheng K.F.
Journal nameInternational Journal of Osteoporosis and Metabolic Disorders
Volume Number5
Issue Number1
PublisherAsian Network for Scientific Information
Place of PublicationPakistan
Pages1 - 12
LanguagesEnglish-United Kingdom
KeywordsBone mineral density, Health supplement, Osteoporosis, Tomography, Traditional chinese medicine

Last updated on 2020-09-07 at 01:30