Bone density and microarchitecture: Relationship between hand, peripheral, and axial skeletal sites assessed by HR-pQCT and DXA in rheumatoid arthritis
Publication in refereed journal


摘要We assessed the relationship of bone density and microarchitecture between hand, peripheral, and axial skeletal sites using high-resolution peripheral quantitative computed tomography (HR-pQCT) and dual-energy X-ray absorptiometry (DXA) in patients with rheumatoid arthritis (RA) and which factors influence these parameters. This was a crosssectional study of 100 female patients (53.4 ± 9.3 years) with RA.HR-pQCT scans at distal radius and the secondmetacarpal head were performed to assess cortical and trabecular volumetric bone mineral density (vBMD) and microarchitecture. DXA scans at the hip, lumbar spine, and ultradistal radius were performed to assess areal BMD. There was significant correlation in vBMDandmicroarchitectural parameters between the second metacarpal head and distal radius (r = 0.201-0.628). Areal BMD at the axial skeleton was moderately associated with vBMD at the peripheral sites (r = 0.354-0.558). Factors related to disease severity/chronicity significantly correlated with vBMD and microarchitecture at the distal radius and the second metacarpal head. Factors related to disease activity were more likely to correlate with vBMD and microarchitecture at the second metacarpal head but not those at the distal radius. HR-pQCT is a promising technique that is capable of providing detailed quantitative assessment of disease-associated periarticular bone loss at both cortical and trabecular bone compartments in patients with RA. Future longitudinal studies will be needed to investigatewhether assessment by HR-pQCT can be used as a marker of disease activity and a predictor of disease progression in RA. © 2012 Springer Science+Business Media, LLC.
著者Zhu T.Y., Griffith J.F., Qin L., Hung V.W.Y., Fong T.-N., Kwok A.W., Leung P.-C., Li E.K., Tam L.-S.
期刊名稱Calcified Tissue International
出版社Springer Verlag
頁次343 - 355
關鍵詞DXA, HR-pQCT, Osteoporosis, Rheumatoid arthritis

上次更新時間 2021-18-09 於 23:42