Association of C2 and CFB polymorphisms with anterior uveitis
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其它資訊
摘要PURPOSE. Association of rs800292 (I62V) in the complement factor H (CFH) gene with anterior uveitis (AU) was identified in our previous study. We proceeded to investigate whether polymorphisms of two tightly linked genes in the complement pathway, complement component 2 (C2) and complement factor B (CFB), are associated with AU. METHODS. Five single-nucleotide polymorphisms (SNPs), rs1048709, rs537160, rs4151657, rs2072633 in CFB, and rs3020644 in C2, were examined using genotyping assays in 98 Chinese AU patients and 291 unrelated controls. Adjustments and stratifications were given for sex, clinical manifestations, and HLA-B27 status. RESULTS. There were significant increases in the frequency of A allele and AA homozygosity for CFB-rs1048709 in AU patients compared with that of controls (P value after Bonferroni correction [Pcorr] = 2.67× 10 -4, Pcorr = 0.001, respectively). No association was found between AU and the other four SNPs after adjustment for multiple testing. Logistic regression analysis showed none of the 5 SNPs had significant interaction with sex. Stratified analyses showed that only rs1048709 was significantly associated with AU in HLA-B27-positive patients but not in HLA-B27-negative patients. No association was found in the 5 tested SNPs with clinical manifestations. A haplotype block across CFB (AATA) was significantly predisposed to AU with increased risk of 1.97 (Pcorr = 0.0005). Additive effect of CFB-rs1048709 and CFH-rs800292 was identified with an odds ratio of 7.48. CONCLUSIONS. Our results revealed an association between AU and CFB-rs1048709. The influence on AU might differ depending on HLA-B27 status. The joint effect in CFB and CFH strengthens the concept that the complement system plays an important role in the pathogenesis of AU. © 2012 The Association for Research in Vision and Ophthalmology, Inc.
著者Yang M.-M., Lai T.Y.Y., Tam P.O.S., Chiang S.W.Y., Ng T.K., Liu K., Pang C.P.
期刊名稱Investigative Ophthalmology & Visual Science
出版年份2012
月份7
日期1
卷號53
期次8
出版社Association for Research in Vision and Ophthalmology
出版地United States
頁次4969 - 4974
國際標準期刊號0146-0404
電子國際標準期刊號1552-5783
語言英式英語

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