Magnesium sulphate for aneurysmal subarachnoid hemorrhage: Why, how, and current controversy
Refereed conference paper presented and published in conference proceedings

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AbstractThe neuroprotective effect of magnesium sulphate infusion has been confirmed in experimental models. Pilot clinical trials using magnesium sulphate in patients with acute aneurysmal subarachnoid hemorrhage (SAH) have reported a trend toward a reduction in clinical deterioration due to delayed cerebral ischemia (DCI) and an improvement in clinical outcomes. However, our recent multicenter trials and systemic review failed to confirm benefit in neurological outcome. In post hoc analysis, data also did not support that a higher dose of magnesium sulphate infusion might improve clinical outcome. We here review the current literature, highlight these discrepancies, and explore alternatives. © 2013 Springer-Verlag Wien.
All Author(s) ListWong G.K.C., Poon W.S.
Issue Number115
PublisherSpringer Verlag
Place of PublicationGermany
Pages45 - 48
LanguagesEnglish-United Kingdom
KeywordsClinical outcome, Delayed cerebral ischemia, Magnesium, Stroke, Subarachnoid hemorrhage

Last updated on 2021-18-09 at 23:41