Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis
Refereed conference paper presented and published in conference proceedings

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AbstractMESP2, HES7 and DUSP6 genes have been proved to be involved in the etiopathogenesis of congenital scoliosis (CS) in animal embryo studies, however, whether this association was detected in human CS patients also remains unknown. One hundred sporadic and non-syndromic CS patients and 100 agematched normal controls were included in this study. Mutation screening of gene exons were performed by DNA sequencing. However, no mutation or new single nucleotide polymorphism was found in the exons of MESP2, HES7 and DUSP6 genes in CS patients and normal controls. MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population. © 2012 The authors and IOS Press. All rights reserved.
All Author(s) ListQiu X.-S., Zhou S., Jiang H., Ji M.-L., Ding Q., Lv F., Liu Z., Tang N., Cheng J.C.Y., Qiu Y.
Name of Conference9th Biennial Meeting of the International Research Society of Spinal Deformities, IRSSD 2012
Start Date of Conference01/07/2012
End Date of Conference04/07/2012
Place of ConferencePoznan
Country/Region of ConferencePoland
Volume Number176
PublisherIOS Press
Place of PublicationNetherlands
Pages52 - 55
LanguagesEnglish-United Kingdom
KeywordsCongenital scoliosis, DUSP6, HES7, MESP2, Mutation

Last updated on 2020-19-10 at 02:49