A synopsis of current haemophilia care in Hong Kong
Publication in refereed journal



摘要Objective To provide a synopsis of current haemophilia care in Hong Kong. Design Retrospective survey. Setting All haematology units of the Hospital Authority in Hong Kong. Patients All patients with haemophilia A and haemophilia B. Results To date, there were 222 mild-to-severe haemophilia patients (192 type A, 30 type B) under regular public care in Hong Kong (43% were considered severe, 33% moderate, and 24% mild), which gave a crude prevalence of 6.8/100 000 male inhabitants. A total of 12.8 million units of Factor VIII and 3 million units of Factor IX were prescribed annually. This amounts to 1.83 units of FVIII per capita of the population, which is comparable to that of other developed countries. Leading causes of mortality were human immunodefciency virus-related complications (10 cases) and cerebral bleeding (2 cases). The life expectancy of patients with severe haemophilia in Hong Kong is improving; currently the oldest patient is 60 years old. Such improved survival may be due to enhanced factor availability, prompt treatment of bleeding episodes at home, safer factor products, and better antiviral treatment. Primary prophylaxis is the accepted standard of care for severe and moderate cases, and "Factor First" has become hospital policy. However, 12 patients continue to present treatment challenges, due to the documented presence of factor inhibitors. In all, 28,100, and 14 cases respectively were positive for human immunodefciency virus, hepatitis C virus, and hepatitis B virus; the youngest patients with the corresponding infections being 28,13, and 22 years old. Comprehensive care with dedicated physiotherapy, surgical support, and radionucleotide synovectomy may reduce morbidity further. Conclusion A multidisciplinary approach can further improve the future care for haemophilia patients in Hong Kong.
著者Au W.Y., Lee V., Kho B., Ling A.S.C., Chan D., Chan E.Y.T., Chan G.C.F., Cheung W.W.W., Lau C.W., Lee C.Y., Li R.C.H., Li C.K., Lin S.Y., Mak V., Sun L., Wong K.H.F., Wong R., Yau J., Yuen H.L.
期刊名稱Hong Kong Medical Journal
出版社Hong Kong Academy of Medicine Press
出版地Hong Kong
頁次189 - 194
關鍵詞Factor VIII, Hemophilia A, HIV infections, Mutation, Survival rate

上次更新時間 2020-29-10 於 00:04