Stereotactic radiotherapy for hepatocellular carcinoma: Report of a local single-centre experience
Publication in refereed journal



摘要Objective To evaluate the efficacy and toxicities of stereotactic radiotherapy for unresectable hepatocellular carcinoma. Design Retrospective study. Setting Prince of Wales Hospital, Hong Kong. Main outcome measures Treatment outcome and toxicities. Patients During the period of 2000 to 2004, 16 patients with hepatocellular carcinoma treated with stereotactic radiotherapy were reviewed. Results Of the 16 patients, 11 had assessable responses. For local control, there were two complete and three partial responses, five with stable disease and one with progressive disease, giving a local response rate of 45% and control rate of 91%. The median survival was 23 months. The 1-year and 3-year overall survival rates were 62% and 28%, respectively. The most frequent site of recurrence was intrahepatic but outside the irradiated field. Two patients with Child-Pugh B cirrhosis developed radiation-induced liver disease. No other grade 3/4 toxicities were recorded. Conclusion Stereotactic radiotherapy gives high local control rates and has the potential to prolong survival in patients with hepatocellular carcinoma. It is safe and tolerable in Child-Pugh A patients. © 1995-2011 HKAM.
著者Chan L.C., Chiu S.K.W., Chan S.L.
期刊名稱Hong Kong Medical Journal
出版社Hong Kong Academy of Medicine Press
出版地Hong Kong
頁次112 - 118
關鍵詞Carcinoma, Chemoembolization, Conformal, Hepatocellular, Liver neoplasms, Radiotherapy, Survival analysis, Therapeutic

上次更新時間 2020-22-11 於 00:43