Identification of source of calcium in HeLa cells by femtosecond laser excitation
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AbstractCalcium is an important messenger in cells and whose store and diffusion dynamics at the subcellular level remain unclear. By inducing a controlled slow subcellular Ca
2+ release through femtosecond laser irradiation in HeLa cells immersed in different media, cytoplasm is identified to be the major intracellular Ca
2+ store, with the nucleus being the minor store and the extracellular Ca
2+ also contributing to the total cellular Ca
2+ level. Furthermore, Ca
2+ released in either the cytoplasm or nucleus diffuses into the nucleus or cytoplasm, respectively, at different rates and influences the Ca
2+ release in those regions. © 2010 Society of Photo-Optical Instrumentation Engineers.
All Author(s) ListHe H., Kong S.K., Chan K.T.
Journal nameJournal of Biomedical Optics
Volume Number15
Issue Number5
PublisherS P I E - International Society for Optical Engineering
Place of PublicationUnited States
LanguagesEnglish-United Kingdom
2+ elevation, Ca
2+ wave, Femtosecond laser, Photostimulation

Last updated on 2021-26-01 at 23:43