Effect of stress on the hypothalamic-pituitary-adrenal axis in the fetus and newborn
Publication in refereed journal

香港中文大學研究人員
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摘要The hypothalamic-pituitary-adrenal (HPA) axis is essential for maintaining homeostasis in the fetus and newborn. A proportion of extremely preterm infants suffer from transient adrenocortical insufficiency of prematurity. Although these infants have suboptimal adrenocortical response to stress in the first week of life, the HPA axis adapts rapidly, and most exhibit an adequate response by day 14. An attenuated cortisol response in preterm infants might be protective against intracranial bleeding. Severe hypoxic-ischemic encephalopathy is a potent stimulus to the HPA axis. Chronic intrauterine hypoxemia can up-regulate the setpoint of the HPA axis and augments adrenal steroidogenic production, resulting in sustained elevation of circulating cortisol levels. © 2011 Mosby Inc. All rights reserved.
著者Ng P.C.
期刊名稱Journal of Pediatrics
出版年份2011
月份2
日期1
卷號158
期次2 SUPPL.
出版社Mosby Inc.
出版地United States
國際標準期刊號0022-3476
電子國際標準期刊號1097-6833
語言英式英語

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