Randomized controlled trial on the safety of intracameral cephalosporins in cataract surgery
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AbstractObjective: To compare the safety profiles of intracameral cephalosporins in cataract surgery. Patients and methods: In this controlled trial, 129 patients were randomized to one of four groups to receive 1 mg of one of three cephalosporins - cefazolin, cefuroxime, or ceftazidime, or normal saline - given intracamerally during cataract surgery. Central endothelial cell density (ECD) and retinal center point thickness (CPT) were determined by specular microscopy and ocular coherence tomography, respectively, before and at 3 months after surgery. Results: There were no statistical significant differences in the changes of ECD and CPT between eyes receiving intracameral cephalosporin and control. Conclusion: The use of intracameral cefazolin, cefuroxime, or ceftazidime (1 mg in 0.1-mL solution) at the time of cataract surgery had no significant effect on ECD and CPT postoperatively. © 2010 Lam et al.
All Author(s) ListLam P.T.H., Young A.L., Cheng L.L., Tam P.M.K., Lee V.Y.W.
Journal nameClinical Ophthalmology
Year2010
Month12
Day1
Volume Number4
Issue Number1
PublisherDove Medical Press Ltd
Place of PublicationNew Zealand
Pages1499 - 1504
ISSN1177-5467
LanguagesEnglish-United Kingdom
KeywordsEndophthalmitis, Intracameral cephalosporin, Phacoemulsification

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