Prediction of distant metastases from nasopharyngeal carcinoma: Improved diagnostic performance of MRI using nodal volume in N1 and N2 stage disease
Publication in policy or professional journal

Times Cited
Altmetrics Information

Other information
AbstractPurpose: To determine if the magnetic resonance imaging (MRI) of the head and neck can predict distant
metastases (DM) from nasopharyngeal carcinoma (NPC).
Methods and materials: MRI examinations of 763 NPC patients were assessed for primary tumour stage
(T), nodal stage (N), primary tumour volume (PTV) and total nodal volume (NV). The association between
MRI and clinical parameters were examined in DM+ and DM patients using logistic regression and for
distant metastases free survival (DMFS) using cox regression. Optimum thresholds were assessed by
receiver-operating characteristics analysis, and positive predictive value (PPV) and odds ratio (OR) calculated.
Results: Distant metastases were present in 181/763 NPC patients (23.7%). Higher N stage and NV were
the independent predictors of DM (p < 0.001 and 0.018 respectively) and poor DMFS (p = 0.001 and 0.030
respectively). Addition of NV (threshold 32.8 cm3) to the N stage improved the PPVs and ORs for DM in
stage N1 (from 18.9% to 31.8% and 5.613 to 11.133 respectively) and stage N2 (from 40.4% to 60.8% and
16.189 to 36.979 respectively) but not in stage N3 (68.3% to 68.6% and 51.385 to 52.052 respectively).
Conclusion: MRI N stage and NV were independent predictors of DM and DMFS. The addition of NV in
NPC patients with bulky N1 and N2 disease improved the ability of MRI to predict DM.
Acceptance Date09/04/2017
All Author(s) ListQi-Yong Ai, Ann D. King, Frankie K.F. Mo, Benjamin King Hong Law, Kunwar S. Bhatia, Brigette B. Ma, Darren M.C. Poon, Michael K.M. Kam
Journal nameOral Oncology
Volume Number69
Pages74 - 79
LanguagesEnglish-United Kingdom
KeywordsHead and neck cancer, Nasopharyngeal carcinoma, Distant metastases, Nodal volume, Prediction
Magnetic resonance imaging

Last updated on 2021-16-01 at 01:14