Pelvic inflammatory disease and the risk of ovarian cancer: a meta-analysis
Publication in refereed journal

替代計量分析
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其它資訊
摘要Purpose:
Previous studies on pelvic inflammatory disease (PID) and the risk of ovarian cancer have found inconsistent results. We performed an updated meta-analysis to summarize the evidence of this association.
Methods:
PubMed, Embase, and ISI web of science databases were searched through October 2016 for studies that
investigated the PID and ovarian cancer association. Summary risk estimates were calculated using random-effects
meta-analysis.
Result:
Thirteen studies were eligible for analysis, which included six cohort studies and seven case–control studies. PID was associated with an increased risk of ovarian cancer overall [relative risk (RR) 1.24, 95% CI 1.06–1.44; I2 = 58.8%]. In analyses stratified by race, a significant positive association was observed in studies conducted among Asian women (RR 1.69, 95% CI 1.22–2.34; I2 = 0%), but marginally significant among Caucasians (RR 1.18, 95% CI 1.00–1.39; I2 = 60.7%).Risk estimates were elevated in both cohort (RR1.32; 95% CI 1.05–1.66; I2 = 64.7%) and casecontrol
studies (RR 1.17; 95% CI 0.93–1.49; I2 = 57.6%), albeit not statistically significant in case–control studies.
Conclusions:
Our results suggested that PID might be a potential risk factor of ovarian cancer, with pronounced associations among Asian women. Large and well-designed studies with objective assessment methods, such as hospital
records, are needed to confirm the findings of this meta-analysis.
出版社接受日期14.02.2017
著者Zhiyi Zhou, Fangfang Zeng, Jianhui Yuan, Jinling Tang, Graham A. Colditz, Shelley S. Tworoger, Britton Trabert, Xuefen Su
期刊名稱Cancer Causes and Control
出版年份2017
月份5
卷號28
期次5
頁次415 - 428
國際標準期刊號0957-5243
電子國際標準期刊號1573-7225
語言英式英語
關鍵詞Pelvic inflammatory disease, Inflammation, Ovarian cancer, Meta-analysis

上次更新時間 2020-19-09 於 02:15