Pelvic inflammatory disease and the risk of ovarian cancer: a meta-analysis
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Previous studies on pelvic inflammatory disease (PID) and the risk of ovarian cancer have found inconsistent results. We performed an updated meta-analysis to summarize the evidence of this association.
PubMed, Embase, and ISI web of science databases were searched through October 2016 for studies that
investigated the PID and ovarian cancer association. Summary risk estimates were calculated using random-effects
Thirteen studies were eligible for analysis, which included six cohort studies and seven case–control studies. PID was associated with an increased risk of ovarian cancer overall [relative risk (RR) 1.24, 95% CI 1.06–1.44; I2 = 58.8%]. In analyses stratified by race, a significant positive association was observed in studies conducted among Asian women (RR 1.69, 95% CI 1.22–2.34; I2 = 0%), but marginally significant among Caucasians (RR 1.18, 95% CI 1.00–1.39; I2 = 60.7%).Risk estimates were elevated in both cohort (RR1.32; 95% CI 1.05–1.66; I2 = 64.7%) and casecontrol
studies (RR 1.17; 95% CI 0.93–1.49; I2 = 57.6%), albeit not statistically significant in case–control studies.
Our results suggested that PID might be a potential risk factor of ovarian cancer, with pronounced associations among Asian women. Large and well-designed studies with objective assessment methods, such as hospital
records, are needed to confirm the findings of this meta-analysis.
Acceptance Date14/02/2017
All Author(s) ListZhiyi Zhou, Fangfang Zeng, Jianhui Yuan, Jinling Tang, Graham A. Colditz, Shelley S. Tworoger, Britton Trabert, Xuefen Su
Journal nameCancer Causes and Control
Volume Number28
Issue Number5
Pages415 - 428
LanguagesEnglish-United Kingdom
KeywordsPelvic inflammatory disease, Inflammation, Ovarian cancer, Meta-analysis

Last updated on 2020-08-08 at 01:02