Hepatic KLF2 Regulates Lipid Metabolism in Obese Mice
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AbstractKruppel-like factor 2 (KLF2) belongs to Kruppel-like factor (KLFs) family. It plays important roles in many biochemical processes, such as lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis. It was reported that KLF2 negative regulated adipogenesis in adipose tissue by inhibition of PPARγ at transcriptional level. But the roles of KLF2 in metabolism in the liver are selfdom studied. Until now, only one report on hepatic KLF2 suggested KLF2 promote steatosis in nonalcoholic fatty liver disease (NAFLD), but the detailed mechanism is unclear. We aim at investigating the regulatory role of KLF2 on lipid metabolism in the liver and the potential effect of KLF2 on diet-induced obesity.
All Author(s) ListHuang Yuhong, Tian Xiao Yu, Huo Mingyu, Luo Jiangyun, Huang Yu
Name of ConferenceThe Cold Spring Harbor Asia Conference on Lipid Metabolism and Metabolic Disorders
Start Date of Conference10/04/2017
End Date of Conference14/04/2017
Place of ConferenceSuzhou
Country/Region of ConferenceChina
LanguagesEnglish-United States

Last updated on 2018-22-01 at 12:49