Group comparison of cortical fiber connectivity map: An application between post-stroke patients and healthy subjects
Publication in refereed journal

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其它資訊
摘要Structural connectome measurement combined with diffusion magnetic resonance imaging (MRI) and tractography allows generation of a whole-brain connectome. However, current cortical structural connectivity (SC) measurements have not been well combined with the vertex-wise multi-subjects statistical analysis. The aim of this study was to examine the feasibility of using group comparison vertex-wise analysis for cortical SC measurement. A fiber connectivity density (FiCD) method based on a combination of a diffusion fiber tracking technique and cortical surface-based analysis was used to measure the whole-brain cortical SC map (FiCD map). A public MRI data set (GigaDB) was employed to evaluate the reproducibility of the FiCD method. For group comparison, 14 post-stroke patients (mean age, 68.36 +/- 7.33 y) and 19 healthy participants (mean age, 66.84 +/- 8.58 y) had FiCD measurement. The intergroup comparison of the FiCD map was performed using vertex-wise multi-subject statistical analysis. Reliability testing showed the mean intra-and inter-subject FiCD variability was 3.51 +/- 2.12% and 19.44 +/- 4.79%, respectively. The group comparison of the whole-brain FiCD identified cortical regions with altered FiCD values, and there was a spatial consistency between the cortical clusters with low FiCD values and the subcortical lesions of patients. This study demonstrated the feasibility of vertex-wise group comparison for evaluating cortical fiber connectivity density. The FiCD method has good intra-and inter-individual reproducibility, and accurately reflects the affected cortical regions in post-stroke patients. This method may be helpful for neuroscience research.
出版社接受日期18.12.2016
著者Kai Liu, Teng Zhang, Winnie CW Chu, Vincent CT Mok, Defeng Wang, Lin Shi
期刊名稱Neuroscience
出版年份2017
月份3
日期6
卷號344
出版社PERGAMON-ELSEVIER SCIENCE LTD
頁次15 - 24
國際標準期刊號0306-4522
電子國際標準期刊號1873-7544
語言英式英語
關鍵詞cortex,connectome,fiber connectivity map,vertex-wise statistical analysis
Web of Science 學科類別Neurosciences;Neurosciences & Neurology

上次更新時間 2020-16-10 於 03:25