A Review on the Sources, Structures, and Pharmacological Activities of Lucidenic Acids
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AbstractGanoderma lucidum has long been used as a multi-purpose plant and functional food. The pharmacological properties of G. lucidum are primarily attributed to its polysaccharides and triterpenoids. Ganoderic and lucidenic acids are the two major triterpenoids groups in G. lucidum. Despite the discovery of 22 types of lucidenic acids, research on lucidenic acids is significantly less extensive compared to that on ganoderic acid. To the best of our knowledge, for the first time, in this review, we aimed to summarize the sources, contents, chemical structures, and pharmacological effects, including
anti-cancer, anti-inflammatory, antioxidant, anti-viral, neuroprotective, anti-hyperlipidemic, anti-hypercholesterolemic, and anti-diabetic properties, of lucidenic acids. Studies on lucidenic acids are still preliminary and have several limitations. Therefore, more in-depth studies with optimal designs are essential for the development of lucidenic acids as medicines, functional foods, and nutraceuticals.
anti-cancer, anti-inflammatory, antioxidant, anti-viral, neuroprotective, anti-hyperlipidemic, anti-hypercholesterolemic, and anti-diabetic properties, of lucidenic acids. Studies on lucidenic acids are still preliminary and have several limitations. Therefore, more in-depth studies with optimal designs are essential for the development of lucidenic acids as medicines, functional foods, and nutraceuticals.
All Author(s) ListChengwen Zheng, Panthakarn Rangsinth, Polly Ho-Ting Shiu, Wen Wang, Renkai Li, Jingjing Li, Yiu-Wa Kwan, George Pak-Heng Leung
Journal nameMolecules
Year2023
Month2
Volume Number28
Issue Number4
PublisherMDPI
Article number1756
ISSN1420-3049
LanguagesEnglish-United Kingdom
KeywordsGanoderma lucidum, lucidenic acids, pharmacological effects
