IL-33 and soluble ST2 levels as novel predictors for remission and progression of carotid plaque in early rheumatoid arthritis: A prospective study
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AbstractObjectives: To study the association between the baseline IL-33 and soluble ST2 (sST2) levels with disease remission and progression of carotid atherosclerosis in early rheumatoid arthritis (ERA) patients. Methods: A total of 98 ERA patients were enrolled. Disease activity and the presence of carotid plaque were evaluated at baseline and 12 months later. Plasma IL-33 and sST2 levels were determined using enzyme-linked immunosorbent assay kits. Results: Baseline IL-33 and sST2 levels were associated with inflammatory markers and cardiovascular (CV) risk factors. Overall, 44(45%), 18(18%), and 21(21%) patients achieved remission based on 28-joint disease activity score (DAS28), Boolean, and simplified disease activity score (SDAI) criteria at 12 months, respectively. Patients with detectable IL-33 at baseline were less likely to achieve DAS28 (P = 0.010) and SDAI remission (P = 0.021), while a lower baseline sST2 level was able to predict DAS28, Boolean, and SDAI remission (P = 0.005, 0.001, and <0.001, respectively). Using multivariate analysis, a lower baseline sST2 level independently predict Boolean (OR = 0.789; P = 0.005) and SDAI remission (0.812; P = 0.008). Regarding carotid atherosclerosis, 9/98(9.2%) patients had plaque progression at 12 months. Baseline IL-33 was detectable in 8/9(89%) and 42/83(51%) of patients with and without plaque progression respectively (P = 0.029). Baseline detectable IL-33 was an independent predictor for plaque progression after adjusting for traditional CV risk factors (P = 0.017). Conclusions: Lower baseline sST2 levels independently predict disease remission and baseline detectable IL-33 independently predicts carotid plaque progression in ERA patients. This study suggests that inflammation induced by the IL-33/ST2 axis may play a significant role in the development of cardiovascular disease in RA.
All Author(s) ListShen J., Shang Q., Wong C.-K., Li E.K., Wang S., Li R.-J., Lee K.-L., Leung Y.-Y., Ying K.-Y., Yim C.-W., Kun E.W., Leung M.-H., Li M., Li T.K., Zhu T.Y., Yu S.-L., Kuan W.-P., Yu C.-M., Tam L.-S.
Journal nameSeminars in Arthritis and Rheumatism
Year2015
Month8
Day1
Volume Number45
Issue Number1
PublisherW. B. Saunders Co., Ltd.
Place of PublicationUnited Kingdom
Pages18 - 27
ISSN0049-0172
eISSN1532-866X
LanguagesEnglish-United Kingdom
KeywordsAtherosclerosis, Carotid plaque, Disease remission, Early rheumatoid arthritis, IL-33, Soluble ST2

Last updated on 2021-18-09 at 23:44