Risk of ischemic stroke after androgen deprivation therapy for prostate cancer in the Chinese population living in Hong Kong
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摘要Objective: Previous reports on the risk of stroke after androgen deprivation therapy for prostate cancer were largely based on Caucasians.We investigated the risk of ischemic stroke after androgen deprivation therapy for prostate cancer in the Chinese population. Methods: All Chinese prostate cancer patients who were treated primarily with radical prostatectomy or radiotherapy, with (androgen deprivation therapy group) or without (non-androgen deprivation therapy group) further androgen deprivation therapy, at our hospital from year 2000-09 were reviewed. Potential risk factors of ischemic stroke including age, baseline prostate-specific antigen, Gleason score, clinical T stage, hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, history of stroke, use of androgen deprivation therapy and duration of androgen deprivation therapy were reviewed. The risk of ischemic stroke after androgen deprivation therapy was analyzed with Kaplan-Meier and multivariate Cox regression analyses. Results: A total of 452 patients were included, consisting of 200 patients in the non-androgen deprivation therapy group and 252 patients in the androgen deprivation therapy group. The androgen deprivation therapy group appeared to have increased risk of ischemic stroke when compared with the non-androgen deprivation therapy group (P = 0.063) upon Kaplan-Meier analysis. Upon multivariate Cox regression analyses, older age (hazard ratio 1.13, 95% confidence interval 1.04-1.22, P = 0.003), hyperlipidemia (hazard ratio 4.61, 95% confidence interval 2.01-10.54, P < 0.001) and the use of androgen deprivation therapy (hazard ratio 3.32, 95% confidence interval 1.14-9.67, P = 0.028) were associated with increased risk of ischemic stroke. Conclusions: Therewas increased risk of ischemic stroke after androgen deprivation therapy for prostate cancer in the Chinese population. The risk of ischemic stroke should be considered while deciding on androgen deprivation therapy, especially in older patients with known history of hyperlipidemia.
著者Teoh J.Y.C., Chiu P.K.F., Chan S.Y.S., Poon D.M.C., Cheung H.Y., Hou S.S.M., Ng C.-F.
期刊名稱Japanese Journal of Clinical Oncology
出版年份2015
月份1
日期1
卷號45
期次5
出版社Oxford University Press
出版地United Kingdom
頁次483 - 487
國際標準期刊號0368-2811
電子國際標準期刊號1465-3621
語言英式英語
關鍵詞Androgen deprivation therapy, Chinese population, Prostate cancer, Stroke