Gelatin embedding: A novel way to preserve biological samples for terahertz imaging and spectroscopy
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AbstractSample dehydration has traditionally been a challenging problem in ex vivo terahertz biomedical experiments as water content changes significantly affect the terahertz properties and can diminish important contrast features. In this paper, we propose a novel method to prevent sample dehydration using gelatin embedding. By looking at terahertz image data and calculating the optical properties of the gelatin-embedded sample, we find that our method successfully preserves the sample for at least 35 h, both for imaging and spectroscopy. Our novel preservation method demonstrates for the first time the capability to simultaneously maintain sample structural integrity and prevent dehydration at room temperature. This is particularly relevant for terahertz studies of freshly excised tissues but could be beneficial for other imaging and spectroscopy techniques.
All Author(s) ListFan S., Ung B., Parrott E.P.J., Pickwell-Macpherson E.
Journal namePhysics in Medicine and Biology
Volume Number60
Issue Number7
PublisherInstitute of Physics Publishing
Place of PublicationUnited Kingdom
Pages2703 - 2713
LanguagesEnglish-United Kingdom
Keywordsdehydration, gelatin, terahertz spectroscopy

Last updated on 2021-16-10 at 23:40