Noninvasive assessments of liver fibrosis with transient elastography and Hui index predict survival in patients with chronic hepatitis B
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AbstractBackground and Aim: The prognostic role of noninvasive assessments of liver fibrosis has been evolving. Our aim was to investigate the prognostic value of liver stiffness measurement (LSM) with transient elastography and serum-based Hui index to predict hepatic events and deaths in chronic hepatitis B (CHB) patients. Methods: The main prospective cohort included 1555 consecutive CHB patients referred for transient elastography examination; a subgroup of 980 patients underwent follow-up assessments at least 3 years later formed the serial cohort. Cox proportional hazard model was performed to determine the relationship of LSM, Hui index and other clinical variables with hepatic events and deaths. Results: During a mean follow-up of 69±9 months, 119 patients (7.6%) developed hepatic events or deaths. Hepatic event-free survival was significantly decreased with increasing stages of LSM and Hui index. The 5-year cumulative probability of hepatic event-free survival of patients of Stage 1-7 of LSM were 99.3%, 98.8%, 95.7%, 90.9%, 89.6%, 74.6%, and 50.0%, respectively; that of Stage 1 to 3 of Hui index were 98.2%, 93.1%, and 77.5%, respectively. Independent predictors of hepatic event-free survival were age, baseline LSM, and follow-up Hui index. Serum ALT and body mass index affected the accuracy of prediction by LSM. Patients remained early stages of LSM or Hui index at follow-up visit had better survival compared to those remained at late stages. Conclusion: Baseline and change in noninvasive parameters of liver fibrosis, LSM and Hui index, are accurate to predict hepatic event-free survival in CHB patients.
All Author(s) ListWong G.L.-H., Chan H.L.-Y., Yu Z., Wong C.K.-Y., Leung C., Ho P.P.-L., Chan C.Y., Chung V.C.-Y., Chan Z.C.-Y., Tse Y.-K., Chim A.M.-L., Lau T.K.-T., Chan H.-Y., Tse C.-H., Wong V.W.-S.
Journal nameJournal of Gastroenterology and Hepatology
Volume Number30
Issue Number3
PublisherBlackwell Publishing Inc.
Place of PublicationUnited Kingdom
Pages582 - 590
LanguagesEnglish-United Kingdom
KeywordsCirrhosis, Clinical events, Death, Hepatocellular carcinoma, Liver stiffness measurement

Last updated on 2021-24-01 at 02:50