Comparison of baseline quality of life scores in patients with bone and brain metastases as assessed using the EORTC QLQ-C15-PAL
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AbstractFrom February 2009 to May 2010, patients receiving treatment for bone or brain metastases from five cancer centers across the world completed the EORTC QLQ-C15- PAL. Demographic information as well as various disease characteristics were recorded. To compare baseline QLQ-C15-PAL scores between patients with bone and brain metastases, univariate linear regression analysis was performed with or without confounders. A Bonferroni adjusted p-value < 0.003 (0.05/15 items) was considered statistically significant. A total of 109 patients with brain metastases and 233 patients with bone metastases completed the QLQ-C15-PAL. As expected, primary cancer site and previous systemic treatments were different between groups: there was a significantly greater number of patients with prostate and renal cell cancers and fewer patients with lung or gastrointestinal cancers with bone metastases, compared to patients with brain metastases (p<0.005). Prior to accounting for these two confounding factors, there were two QLQ-C15-PAL symptom scales significantly different between patients with bone metastases and patients with brain metastases. Patients with bone metastases had greater severity in pain (baseline mean score: 53.7 vs. 22.8; p<0.001) and fatigue (47.8 vs. 40.4; p=0.0029), compared to those with brain metastases. After accounting for confounders, only pain was significantly different (p<0.0001). Patients with bone metastases experience more pain at baseline compared to those with brain metastases. Patients with either bone or brain metastases otherwise experienced similar QOL profiles as assessed by the QLQ-C15-PAL. Supplementing of QLQ- C15-PAL by disease-specific instruments such as the QLQ- BM22 or QLQ-BN20 is therefore recommended in future trials depending on patient population included. © Nova Science Publishers, Inc.
All Author(s) ListDi Giovanni J., Zeng L., Zhang L., Vassiliou V., Satoh T., Foro P., Ma B.B.Y., Chie W.-C., Sahgal A., Poon M., Chow E.
Journal nameJournal of Pain Management
Volume Number6
Issue Number2
PublisherNova Science Publishers, Inc.
Place of PublicationUnited States
Pages151 - 157
LanguagesEnglish-United Kingdom
KeywordsBone metastases, Brain metastases, EORTC, QLQ-C15-PAL, Quality of life, Radiotherapy

Last updated on 2020-02-09 at 00:42