International survey of T2* cardiovascular magnetic resonance in β-thalassemia major
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摘要Accumulation of myocardial iron is the cause of heart failure and early death in most transfused thalassemia major patients. T2* cardiovascular magnetic resonance provides calibrated, reproducible measurements of myocardial iron. However, there are few data regarding myocardial iron loading and its relation to outcome across the world. A survey is reported of 3,095 patients in 27 worldwide centers using T2* cardiovascular magnetic resonance. Data on baseline T2* and numbers of patients with symptoms of heart failure at first scan (defined as symptoms and signs of heart failure with objective evidence of left ventricular dysfunction) were requested together with more detailed information about patients who subsequently developed heart failure or died. At first scan, 20.6% had severe myocardial iron (T2*≤10ms), 22.8% had moderate myocardial iron (T2* 10-20ms) and 56.6% of patients had no iron loading (T2*>20ms). There was significant geographical variation in myocardial iron loading (24.8-52.6%; P<0.001). At first scan, 85 (2.9%) of 2,915 patients were reported to have heart failure (81.2% had T2* <10ms; 98.8% had T2* <20ms). During follow up, 108 (3.8%) of 2,830 patients developed new heart failure. Of these, T2* at first scan had been less than 10ms in 96.3% and less than 20ms in 100%. There were 35 (1.1%) cardiac deaths. Of these patients, myocardial T2* at first scan had been less than 10ms in 85.7% and less than 20ms in 97.1%. Therefore, in this worldwide cohort of thalassemia major patients, over 43% had moderate/severe myocardial iron loading with significant geographical differences, and myocardial T2* values less than 10ms were strongly associated with heart failure and death. © 2013 Ferrata Storti Foundation.
著者Carpenter J.-P., Roughton M., Pennell D.J., He T., Kirk P., Anderson L.J., Porter V.J.B., Malcolm Walker J., Galanello R., Danjou F., Forni G., Kattamis A., Ladis V., Drossou M., Vini D., Michos A., Perifanis V., Hazirolan T., Almeida A., Aydinok Y., Bayraktaroglu S., Rangelova M., Stoyanova D., Kaleva V., Tonev G., El-Beshlawy A., Elalfy M., Al-Nasser I., Au W.-Y., Ha S.-Y., Li C.-K., Chiu-Wing Chu W., Chan L.-L., Lu M.-Y., Wahidiyat L., Merelles-Pulcini M., Fernandes J.L., Kay F., Joy Ho P., Hankins J.S., Cappellini M., Daar S., Sathar J., Taher A., Kontoghiorges G., Belhoul K., Thompson A., Kwiatkowski J.L., Tan R.-S., Thuret I., Badens C.
期刊名稱Haematologica
出版年份2013
月份9
日期1
卷號98
期次9
出版社Ferrata Storti Foundation
出版地Italy
頁次1368 - 1374
國際標準期刊號0390-6078
語言英式英語

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